Hernandez, I.L.C., Macedo, M.L., Berlinck, R.G.S., Ferreira, A.G., Godinho, M.J.L., “Dipeptide metabolites from the marine derived bacterium Streptomyces acrymicini”, J. Braz. Chem. Soc., 2004, 15, 441-444.

The chemical investigation of the crude extract obtained from the growth media of the marine-derived actinomycete Streptomyces acrimycini isolated from marine sediments led to the isolation of two new dipeptide derivatives: 8-amino-[1,4]diazonane-2,5-dione (1) and leucyl-4-hydroxyproline (3). The dipeptides were isolated from the growth media by a series of chromatographic steps, and identified by analysis of spectroscopic data. The macrocyclic carbon backbone of 8-amino-[1,4]diazonane-2,5-dione has been previously reported only once in marinobactins, siderophores isolated from the marine bacterium Marinobacter sp.